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KMID : 0882420070730060587
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Korean Journal of Medicine
2007 Volume.73 No. 6 p.587 ~ p.595
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Relationship of body iron stores with the development of nonalcoholic fatty liver disease
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Hwang Sang-Jun
Cho Yong-Kyun
Oh Se-Yong
Choi Hyo-Sun
Park Jung-Sik
Kim Shin-Yun
Park Jung-Ho
Kim Hong-Joo
Park Dong-Il
Sohn Chong-Il
Jeon Woo-Kyu
Kim Byung Ik
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Abstract
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Background : Although numerous reports have shown the influence of the iron overload state on the development of nonalcoholic fatty liver disease (NAFLD), there have been few reports on the prevalence of NAFLD according to the body iron stores. The aim of the present study was to determine the relationship of body iron stores with the development of NAFLD in apparently healthy women.
Methods : The present cross-sectional study was performed with data obtained from 5,249 women (mean age: 40.6±8.9 years), that received an annual health check-up. All components of metabolic syndrome criteria, anthropometric parameters, fasting insulin levels, level of C-reactive protein and serum iron tests were measured in each subject.
Results : The prevalence of NAFLD was significantly different according to body iron status (normal iron store/iron store depletion/iron deficient erythropoiesis/iron deficiency anemia: 10.6%/4.1%/6.5%/11.2%, p<0.001). Multivariate analysis revealed that age (odds ratio [OR]=1.284; 95% confidence interval [CI]: 1.1161.507) per 10 years), being overweight (OR=1.952; 95% CI: 1.3952.732), diabetes mellitus (OR=1.694; 95% CI: 1.198-2.397), hypertriglyceridemia (OR=2.434; 95% CI: 1.737-3.409), abdominal obesity (OR=3.559; 95% CI: 2.538-4.992), insulin resistance (OR=2.665; 95% CI: 1.979-3.587), anemia (OR=2.015; 95% CI: 1.150-3.532) and stored iron depletion (OR=0.580; 95% CI: 0.405-0.830) were profoundly associated with the development of NAFLD.
Conclusion : The present study reveals a possible correlation between the development of NAFLD and body iron stores, and stored iron depletion and anemia seem to be key factors for this correlation.
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KEYWORD
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Nonalcoholic fatty liver disease, Iron status, Iron deficiency, Anemia
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